Notably, Roquin2 expression negatively correlated with the expression of proangiogenic factors, including ENG, EDN1, VEGFB, platelet endothelial cell adhesion molecule-1 (PECAM1), Angiogenin (ANG), tyrosine kinase with immunoglobulin like and EGF like domains 1 (Tie1), and EphB4 type-B receptor 4 (EPHB4) in human breast tumors. This evidence concerns the gene TIE1 and breast neoplasm.