Moreover, there was a significant negative correlation between Roquin2 expression and the expression of angiogenic genes, including PECAM1, ENG, EDN1, VEGFB (Fig. 7F), and ANG, TIE1, EPHB4 (Supplemental Figure 8D) in 1,006 human breast cancer samples, although no significant correlation between Roquin2 and PDGFC (data not shown) (Oncolnc.org/). This evidence concerns the gene EPHB4 and breast cancer.