The density of CD31-positive microvessels in Roquin2-adenovirus treated tumors was reduced compared with those of the tumors treated with control adenovirus (Fig. 7D), which was in line with above in vivo results (Fig. 2) and further confirmed the inhibitory effects of Roquin2 on tumor angiogenesis. The gene discussed is PECAM1; the disease is neoplasm.