CASP3 and neoplasm: The impaired tumor growth, improved mice survival, decreased Ki-67 staining and increased number of cleaved caspase-3-positive cells were also observed from the patient-derived xenograft (PDX) model that better reflects tumor heterogeneity (P < 0.05, P = 0.003 and P = 0.006; Figure 7L-N and S6F).