PKM and neoplasm: To gain insight into the relevance of ULK1/2,YAP and PKM2 in PDAC, levels of ULK2,YAP and PKM2 protein expression in tumour tissues from KPC (Pdx1-Cre; LSL-KrasG12D/+; Trp53fl/+) mice were examined by immunohistochemical staining, which revealed that ULK2,YAP and PKM2 were strongly expressed in KPC tumour tissues (P < 0.0001, Figure 6A and Figure S5A).