PKM and pancreatic adenocarcinoma: In addition, survival analyses of 177 pancreatic adenocarcinoma patient from TCGA datasets demonstrated that patients with the combination of high ULK1/2, YAP1 and PKM signature displayed shorter overall survival than those with low ULK1/2, YAP1 and PKM signature (Log-rank test, P = 2.3e-05 and P = 1e-05, Figure S5D), implying that both transcriptomic and genomic upregulation of these three genes may reflect PDAC tumorigenesis.