Moreover, lncRNAs HOXD-AS1 64, FAM84B-AS 65, TP73-AS1 66, ASB16-AS1 67, PVT1 68 and HOTTIP 69 also conferred the resistance of GC cells in response to DDP via regulating expression levels of MDR-associated genes. The gene discussed is HOTTIP; the disease is gastric cancer.