YTHDF3 was a novel target of YAP, which could facilitate the degradation of m6A modified lncRNA GAS5, thus uncovering a negative functional loop of lncRNA GAS5-YAP-YTHDF3 axis, and identifying a novel mechanism for m6A induced decay of GAS5 on YAP signaling in the progression of colorectal cancer 138. This evidence concerns the gene GAS5 and colorectal cancer.