Moreover, circ-KIAA1244 was reported to be detected in GC patients' plasma exosomes, and low expression of plasma circ-KIAA1244 could inhibit lymphatic metastasis and increase overall survival rate, which indicated that circ-KIAA1244 might serve as a novel circulating biomarker for the detection of GC metastasis 151. This evidence concerns the gene ARFGEF3 and gastric cancer.