TGFB1 and cystic fibrosis: Thisinduction inhibits actions of pro-inflammatory cytokines of the TGFβ superfamilyon the β-cells.75 Macrophages are also important regulators of angiogenesis in the isletsand protect from islet cell loss in mice.76 The importance of macrophage and β-cell crosstalk in β-cell regenerationin both T1D and T2D is well researched.77 Macrophages are greatly decreased in pancreatic islets from adultpatients with CF.74 However, the role of macrophages in CF islet pathology and inflammationis not established.