There is data from rodent models supporting that CFTR may be more expressed inα-cells compared to β-cells40 and that functional impact of dysfunctional CFTR may therefore be moreimportant in this cell type.62,63 However, the current lackof understanding of α-cell secretory and membrane physiology in general makesthe translation of this effect in CF and CFRD patients more difficult. The gene discussed is CFTR; the disease is cystic fibrosis.