It also highlights how ductal obstruction can lead to furtherinflammation and auto digestion.16 The cell type of the pancreas that has the highest expression of CFTR arethe ductal cells.42 It is established that dysfunctional CFTR in ductal cells leads to lowerluminal pH and disrupts the function of the secreted digestive enzymes, leadingto pancreatic insufficiency.33,66,67. This evidence concerns the gene CFTR and exocrine pancreatic insufficiency.