KRAS, a monomeric membrane-localized GTPases, is the most frequently mutated RAS isoform in various cancers, such as pancreatic adenocarcinoma (90%), colorectal cancer (45%) and lung adenocarcinoma (35%), and has been found to play pivotal role in oncogenesis [34, 35]. This evidence concerns the gene KRAS and pancreatic adenocarcinoma.