When compared to their corresponding control cells, LV-sh-RNF141-transfected CRC cells exhibited a higher percentage of apoptotic cells (Annexin V-positive cells) in HCT116 (16.92 ± 0.37% vs 9.56 ± 0.43%), SW480 (14.55 ± 0.85% vs 8.80 ± 0.52%), DLD-1 cells (24.95 ± 0.66% vs 16.37 ± 0.27%) and HT29 (20.87 ± 0.54% vs 12.93 ± 0.51%) (Fig. 3A). Here, RNF141 is linked to colorectal carcinoma.