GRB2 and esophageal squamous cell carcinoma: Clinically, we found higher m5C and RNA levels of GRB2 in tumors than in adjacent normal tissues from our 215 paired ESCC cohort (Fig. 4F; Fig. 7A; Supplementary Table 1−2) and from the seven paired sequencing ESCC samples (Fig. 4G; Fig. 7B; Supplementary Table 7).