IL18 and adult-onset Still disease: To validate AOSD sera-induced NETs in an mROS-dependent manner is associated with IL-18, we examined the effect of IL-18 on mitochondrial membrane potential (MMP) using MITO-ID dye (Fig. 2b) and tetraethyl benzimidazolyl carbocyanine iodide (JC-1) staining (Fig. 2c).