IL10 and systemic lupus erythematosus: REACTOME Reactions and Pathways analyses21 revealed significant changes in gene expression involved in extracellular matrix (ECM) organisation, immune system activation through CD3, and cytokine/chemokine regulation that involved IL-10 signalling and trafficking in inflammation sites12,22, with the majority of genes in the SLE-derived PB progenitors, being upregulated in comparison to Healthy-derived PB (Supplementary Fig. 2B).