SLE PB-derived progenitor DEGs revealed a marked upregulation in SIRT7 and a downregulation in NRF1 and NRF1-dependent DEGs (131 genes), while LXR (NR1H3)-dependent gene expression showed mixed DEG patterns (36 genes), when compared to SLE BM-derived HSPCs (Fig. 3A,B and Supplementary Fig. 5A). Here, SIRT7 is linked to systemic lupus erythematosus.