GSDMA and cancer: Finally, the topic timeline the members of the pyroptosis pathway (CGAS, TMEM173, GSDMA and GSDMAD; Fig. 4C) shows a fast increase from 2013 of publications discussing the therapeutic opportunity in cancer immunotherapy with agonists for TMEM173 (Fig. 4B in grey), while again, the remaining topics seemed to contain information on the biochemistry and biological role of the genes.