The topic timeline of the members of the necroptosis pathway (RIPK1, RIPK3 and MLKL; Fig. 4B) suggests that in the last decade there has been a decrease in the likelihood of publications discussing these genes in the context of apoptosis (Fig. 4B in grey), in favour of publications that discuss the newly discovered form of cell death, the necroptotic pathway (Fig. 4B in orange), as well as, the translational medicine perspective of this pathway as is suggested by words like mouse, treatment and activity or cancer (Fig. 4B, in blue). The gene discussed is MLKL; the disease is cancer.