The most significantly mutated genes include FBXW7 (encoding WNT signaling molecule) in B-cell lymphoma, SATB1 (functioning in chromatin remodeling) in T-cell lymphoma, and CALD1 (encoding an actin and myosin binding protein) in glioma (Fig. 3a). The gene discussed is FBXW7; the disease is T-cell non-Hodgkin lymphoma.