IFIH1 and bacterial infectious disease: LGP2 facilitates MDA5 fiber assembly and is incorporated into the fibers, forming hetero-oligomers with MDA5.127 In addition, LGP2 can significantly induce the exposure of the CARD domain of MDA5.128 Under bacterial infection of the Indian major carp Labeo rohita, LGP2 gene expression was significantly increased after dsRNA and various PAMPs were stimulated, indicating that LGP2 can act as an antiviral and antibacterial cytoplasmic receptor.129