Newborns with chronic obstructive jaundice make their livers prone to cholestatic liver disease, and biliary atresia (BA) accounts for half of the cases.384 Viruses have always been considered as the causative pathogen of this disease, and the role of TLRs in the pathogenesis and progression of BA has been determined.385 Subsequent studies have shown that activation of TLR7 can induce type 1 IFN signal transduction, apoptosis, and dysplasia of the neonatal liver and biliary system. The gene discussed is TLR7; the disease is breast angiosarcoma.