Once this pathway is opened, it may induce the secretion of matrix metalloproteinase-13 (MMP-13) and the activation of intercellular adhesion molecule-1, thus promoting the metastasis of tumor cells.335,336 At the same time, the metastatic tumor cells are better adapted and combined with the cell matrix at the metastasis, and the stability of tumor cell metastasis is enhanced. Here, ICAM1 is linked to neoplasm.