RLRs are involved in the recognition of viral infection by the innate immune system, and their agonists include poly I:C.99 Studies have revealed the link between energy metabolism and innate immunity, indicating that lactate may act as a natural inhibitor of RLR signal transduction by targeting the adaptor protein MAVS.458 The latest research shows that activating RIG-I before diffusing alpha-emitting radiation therapy for metastatic and low immunogenic tumors is a more effective combination therapy technique that can inhibit tumor growth and metastasis.459. This evidence concerns the gene RIGI and viral infectious disease.