For TLR3, the downregulation of TLR3 in HCC patients leads to poor prognosis (e.g., defective immune cell recruitment and lack of killing of transformed hepatocytes), leading to protection of transformed hepatocytes from apoptosis, thereby promoting the occurrence of liver cancer.348 Therefore, the expression of TLR3 may become a useful clinical treatment monitoring marker. Here, TLR3 is linked to hepatocellular carcinoma.