CRP generally binds to phosphocholine expressed on the surface of pathogenic microorganisms in a Ca+-dependent manner.217 SAA can bind to the outer membrane protein A of bacteria and interact with TLRs.218,219 In clinic, SAA and CRP are usually used as auxiliary diagnostic indicators for infectious diseases, but studies have shown that they also have diagnostic value in non-infectious diseases and can be used as disease classification markers.220,221 The representative of the pentraxin long molecule family is PTX3,222 which is unique in that it has a long N-terminal domain. The gene discussed is CRP; the disease is infectious disease.