CYBB and immune system disorder: The initial stage usually manifests as fatty liver, which can then develop into alcoholic hepatitis, liver fibrosis, and cirrhosis.392,393 Patients with advanced alcoholic cirrhosis are more susceptible to infection.394 This phenomenon is related to multiple organ failure and immunodeficiency and is usually manifested as insufficient antibacterial activity of neutrophils.395 The neutrophil function to resist microbial infections needs to generate reactive oxygen species through NADPH oxidase 2.