Similar results were found in rodent in vivo models of CLL, T-cell acute lymphoblastic leukaemia (T-ALL) [18], GBM [25], cholangiocarcinoma [50] using THZ1 and leukaemia model [17] and MYCN-amplified neuroblastoma [41] using CYC065. Here, MYCN is linked to T-cell acute lymphoblastic leukemia.