Therapeutic effectiveness of HLA-G blockade using TTX-080, a monoclonal antibody targeting HLA-G, is currently underway in clinical trials of patients with solid tumours.49 In addition, combination therapy targeting HLA-G concomitantly with other immune CPIs has been suggested in non-responder patients with cancer to CPI monotherapy.50 However, early results from the current clinical trials are required before further consideration of this treatment strategy. The gene discussed is HLA-G; the disease is cancer.