CD4+ T cells expressing HLA-G have been shown to act as suppressive cells by dampening lymphocyte-driven immune responses.32 33 To explore their regulatory capacity in patients with AD, magnetically cell-sorted CD4+HLA-G+ T cells were incubated at increasing ratios with CPD-labelled allogeneic PBMCs in the presence of anti-CD3 polyclonal stimulation. This evidence concerns the gene CD4 and Alzheimer disease.