In previous studies, CD4+HLA-G+ cells from healthy individuals were reported to produce high levels of IL-10 and exert their suppression in an IL-10-dependent manner.33 In contrast, CD4+HLA-G+ T cells from patients with AD were weak producers of IL-10 suggesting that their suppressive functions were unlikely to be supported by IL-10. The gene discussed is IL10; the disease is Alzheimer disease.