MUC5B and interstitial lung disease: The common variant rs35705950 in the MUC5B promoter is strongly associated with upregulation of MUC5B expression in the lungs, and the general association between the variant and ILD has been widely replicated.10 11 14 In addition, evidence from fine-mapping indicates that rs35705950 might be a causal variant: Bayesian fine-mapping analyses of genome-wide association study (GWAS) results can be used for defining variant sets (credible sets), that with high probability contain one or several causal variants.