MUC5B and interstitial lung disease: A case–control study by Juge and colleagues recently demonstrated enrichment of MUC5B carriers in patients with RA-ILD, with supporting evidence from gene expression in lung parenchyma and high-resolution imaging.11 Using large-scale biobank data, we now show how this finding translates to lifetime risks and demonstrate the potential of genomics for risk stratification of RA-ILD and early identification of patients.