Additionally, miR-21-5p could inhibit TGFBR2 expression in the TGF-β signaling pathway, thereby suppressing myofibroblast differentiation, in contrast to other reports, in which miR-21-5p promoted gastric cancer and kidney fibrosis by upregulating Smad7 in the TGF-β signaling pathway [35, 36]. This evidence concerns the gene SMAD7 and gastric cancer.