The macrolid Rapamycin, an immunosuppressant used in transplant, inhibits JNK and the Akt/mTOR complex, and prevented or even reversed cardiac hypertrophy in a transgenic mouse model with Ptpn11-Y279C that causes cardiac hypertrophy (Ptpn11 is a SHP2 protein, Fig. 1) [107]. The gene discussed is MAPK8; the disease is cardiac hypertrophy.