In mouse models of acute myeloid leukemia, Lehnertz et al. established EHMT2 as a selective regulator of fast proliferating myeloid progenitors, indicated by the evidence that loss of EHMT2 significantly delays disease progression and reduces leukemia stem cell frequency by interacting with the leukemogenic transcription factor HoxA9 [27]. The gene discussed is HOXA9; the disease is leukemia.