In accordance with this observation, the results of our in vitro study confirmed that CXCR4 is expressed on cultured SSc fibrocytes; however, the treatment with nintedanib did not modulate its gene expression and protein synthesis, suggesting that this tyrosine kinase inhibitor might not block the capability of fibrocytes to migrate into the tissue at least by interfering with the CXCL12/CXCR4 pathway. Here, CXCR4 is linked to systemic sclerosis.