GRN and Adult onset: Dosage of PGRN plays a central role in its cellular functions as haploinsufficiency of PGRN leads to an adult-onset neurodegenerative disorder, frontotemporal lobar degeneration (FTLD-TDP-Pgrn), while complete loss of PGRN leads to a childhood lysosomal storage disorder called neuronal ceroid lipofuscinosis (NCL) [3–5].