Fibroblast growth factor receptors 1–4 (FGFR1-4) form a family of four highly conserved RTKs and deregulation of FGFR signaling, reflecting gene mutation, translocation, amplification and/or overexpression, occurs in a variety of human malignancies including urothelial (32% of cases) and breast cancers (18%) [9, 10]. Here, FGFR1 is linked to breast cancer.