These include the hepatocellular carcinoma-related protein 1 (HCRP1, gene name: VPS37A) and the phosphoinositide (PIP) phosphatase MTMR7, which were downregulated in EGFR-mutated lung tumors, consistent with their ability to inhibit EGFR phosphorylation and signaling [35–38], the hypoxia-associated genes NBN and OSGIN2 [39, 40], and the tumor suppressive gene cluster TNSRSF10(A/B/C/D), which were downregulated together with RHOBTB2, another tumor suppressor gene [41, 42]. This evidence concerns the gene OSGIN2 and neoplasm.