In parallel to their multi-kinase inhibitory activity, cardiac peptides are also capable of attenuating secretion of VEGFA, downregulate expression of VEGF receptor 2 (VEGFR2) expression, and inhibit activation of the Signal Transducer and Activator of Transcription 3 (STAT 3), all of which are effective approaches for suppressing pro-angiogenic responses in tumor site. Here, STAT3 is linked to neoplasm.