NFE2L2 and fatty liver disease: In macrophages, scoparone can alleviate lipopolysaccharide-induced immune responses partly by blocking TLR-4/NF-κB signaling, and regulate autophagy by inhibiting the ROS/P38/Nrf2 axis; and in an MCD diet-induced NASH murine model, it can improve hepatic steatosis, apoptosis, inflammation, and fibrosis [51, 52].