CD4 and neoplasm: NK cell (p  <  0.001), CD8  +  T cell (p  <  0.001) and myeloid dendritic (p  <  0.001) cell (Additional file 9: Figure S9E–G) were higher in normal tissue estimated in MCP while CD4  +  T cell (p  <  0.01; Additional file 9: Figure S9H) was lower expressed in tumor tissue through calculation in EPC.