Moreover, low expression of ACLY and CD276 with high infiltration level of CD8  +  T cell turned out to contribute to the best survival outcome (KM curve: TMR: HR  =  0.279; p  =  0.003; MCP: HR  =  0.479; p  =  0.060; CBS: HR  =  0.401; p  =  0.031; Fig. 7R, S) in HCC. This evidence concerns the gene CD276 and hepatocellular carcinoma.