Our synthesized results revealed significantly lower levels of immune cells in CD3+ T, CD4+ T, CD8+ T, B and NK cells, higher levels of cytokines (TNF-α, IL-5, IL-6 and IL-10) and higher levels of chemokines (MCP-1, IP-10 and eotaxin) in severe cases compared with mild cases of COVID-19. This evidence concerns the gene IL10 and COVID-19.