NLRP3 and myocardial infarction: So far, little is known about the functional consequences of the investigated SNPs in the regulatory region of NLRP3. NLRP3 mRNA expression was lower in PBMCs isolated from carriers of the major alleles of rs4353135 and rs10733113 in the CD-cohorts studied by Villani et al. and in patients with myocardial infarction and healthy controls [1, 13].