ANGPT1 and type 2 diabetes mellitus: Therefore, the total amount of Ang1 detected at 3 h post-treatment was considered as being almost completely released, indicating a significant increase of Ang1 synthesis (up to 1.98-fold; 202 vs 112 pg/mL) in neutrophils from HC, and this effect was amplified in PMA and A23187 stimulated neutrophils from T2DM patients (up to 2.91-fold; 201 vs 69 pg/mL).