In western blot, we found that p-CaMKII, p-PLC-γ, and p-IP3R were increased in the MI/R group and reduced in the Allicin group m-3M3FBS could reverse the decrease of p-CaMKII, p-PLC-γ, and p-IP3R expression levels. This evidence concerns the gene ITPR1 and myocardial infarction.