Thus, it is expected that kinetics stabilizers that mimic the T119M stabilizing effect, such as Tafamidis (17, 45), Diflunisal (46), Tolcapone (20, 47), or AG10 (48, 49), would become effective drugs to treat the TTR amyloidosis associated with BC-loop fluctuations. The gene discussed is TTR; the disease is amyloidosis.