RBBP8 and neoplasm: To determine whether the expression of the host factors involved in MRN (MRE11-RAD50-NBS1)-CtIP-dependent MMEJ might be altered during MmuPV1 infection and papilloma induction, we analyzed two separate RNA-seq datasets [42, 56] to determine if there was an increase in the expression of DNA repair genes, particularly in the 21 genes involved in MMEJ [26] in MmuPV1-induced tumor tissues compared to the MmuPV1-infected tumor-free or normal control tissues (S9 Table).