Notably, Nodamura virus (NoV), influenza A virus (IAV), human enterovirus 71 (HEV71), and dengue virus-2 (DNV2) from 4 distinct RNA virus families encode structurally unrelated VSRs necessary for infection and active to suppress Dicer processing of the cognate viral dsRNA replicative intermediates (dsRNA-vRIs) into vsiRNAs [23–25,27,29]. The gene discussed is DICER1; the disease is infection.