We propose that prior production of SINVNoV-targeting vsiRNAs induced by NoVΔB2 immunization in BALB/c and Ifnar1-/- suckling mice directed suppression of virus infection by RNAi in a mechanism similar to the sequence-specific protection from incoming RNA viruses in Ifnar1-/- MEFs induced by transfection with long dsRNA [42]. This evidence concerns the gene IFNAR1 and viral infectious disease.