Deep sequencing of small RNAs showed that whereas both the strand ratio and the size preference of the vsiRNAs were similar, the relative abundance of vsiRNAs triggered by NoVΔB2 infection was higher in Dhx58-/- mice (2.7%) than in wild-type mice (1.0%) (Figs 3A and 6E and S1 Table). Here, DHX58 is linked to infection.