AKT1 and adenocarcinoma: In addition, verbascoside, a phenylethanoid glycoside found in plantago seeds, was found to downregulate the phosphatidylinositol 3-kinases (PI3K)/protein kinase B (Akt) pathway, leading to the sensitization of HCT116 and Caco-2 adenocarcinoma cells to 5-FU [25].