Moreover, ethanolic extracts of the leaves of C. gigantea have been shown to inhibit the growth of fibrosarcomas through the upregulation of caspase-3 expression (apoptotic index and immunohistochemistry caspase-3 score) in a 7,12 dimethylbenz(α) anthracene acetone-induced mouse model [45]. This evidence concerns the gene CASP3 and fibrosarcoma.