IL4 and asthma: T2-high asthma is the most frequent endo/phenotype and is canonically marked by activation of type 2 helper (Th2) cells, type 2 innate lymphoid cells (ILC2s), mast cells, basophils, eosinophils and the production of type 2 cytokines (e.g., IL-3, IL-4, IL-5 and IL-13) [8–10].