C3 and asthma: Among these, LPS [60, 75, 131, 132], IL-17 [133], IL-33 [134, 135], CXCL8 [60, 136–138], C3a/C5a [75, 139, 140] and IL-1β [45, 141], which have been implicated in various aspects of asthma [42, 45], are inducers of NET formation in neutrophils.