It has been reported that inflammatory response plays a critical role in tumor initiation, promotion, malignant conversion, invasion, and metastases.27 Inflammation also affects patient survival by regulating responses to therapy and immune surveillance.28 Specifically, research about the action of inflammation in promoting KRAS-driven oncogenesis has confirmed that inflammation collaborates with KRAS signaling to promote carcinogenesis.29KRAS is a target of let-7a in osteosarcoma. This evidence concerns the gene KRAS and osteosarcoma.