Our occlusion sensitivity analysis revealed that many of the important factors were those associated with a history of preexisting lung conditions (eg, postinflammatory pulmonary fibrosis and pneumococcal pneumonia) and medications used to treat smoking-related diseases (eg, buflomedil for peripheral arterial disease and angina pectoris, and insulin for insulin resistance of diabetes mellitus) with increased cancer risk (eg, congenital anomalies of the circulatory system [37] and periodontal conditions [38]), and paraneoplastic phenomena (eg, noninfectious gastroenteritis and colitis [39]). The gene discussed is INS; the disease is pneumococcal pneumonia.