PNMT and adrenal gland neoplasm: Noradrenergic tumours are located either in the adrenal medulla or extra-adrenal sites and produce norepinephrine.4 The lack of epinephrine secretion in extra-adrenal tumours is because of the absence of the enzyme phenylethanolamine-N-methyltransferase (PNMT), which is essential for converting norepinephrine to epinephrine.20