The role of LITAF in maintaining membrane organisation during endosomal recycling is likely to be important for understanding CMT disease, and is consistent with other studies linking demyelinating forms of CMT to mutations in endocytic regulators that impair exit from the early endosome (Azzedine et al., 2012; DiVincenzo et al., 2014). Here, LITAF is linked to Charcot-Marie-Tooth disease.