Other studies have demonstrated that DR4 localization into LRs is obligatory for TRAIL-induced apoptosis in hematological malignancies and non-small cell lung cancer, whereas DR5 has no dependence on raft translocation (Marconi et al., 2013; Naval et al., 2019; Ouyang et al., 2013; Song et al., 2007), consistent with our correlative data and receptor contents from LR-isolated membrane fractions. This evidence concerns the gene TNFRSF10B and hematologic disorder.