INS and liver disorder: It was shown before that physical exercise in humans and rodents counteract the different stages of the development of NASH (Bae et al., 2012; Guo et al., 2015; Hallsworth & Trenell, 2020; Nath et al., 2020; Thorp & Stine, 2020; Van der Windt et al., 2018), and exercise positively modulates the murine liver genetic profile through a decrease in pathways related to insulin resistance, steatosis, fibrosis, and inflammation, suggesting a therapeutic strategy for liver diseases (Melo et al., 2021).