Overexpression of S100A6 is correlated with patient prognosis, so it is an independent prognostic predictor in gastric cancer and the methylation profile of specific CpG sites may affect its transcription.41 S100A6 can not only stimulate proliferation and migration of colorectal carcinoma cells through activation of the MAPK pathways,42 but also regulate the proliferation, invasion, migration and angiogenesis of lung cancer cells through the p53 acetylation.43 Moreover, it plays an important role in pancreatic cancer44, 45. The gene discussed is TP53; the disease is lung cancer.