SORBS2 (sorbin and SH3 domain containing 2) is an RNA binding protein. Previous studies have indicated that it is a tumour suppressor and can suppress the metastasis of many cancer. For example, it can suppresses metastatic colonization of ovarian cancer by stabilizing tumour‐suppressive immunomodulatory transcripts.27 Mediated by MEF2D, it suppresses the metastasis of human hepatocellular carcinoma by inhibiting the c‐Abl‐ERK signalling pathway,28 as well as hepatocellular carcinoma tumorigenesis29 and cervical carcinogenesis30. This evidence concerns the gene SORBS2 and hepatocellular carcinoma.