Whereas aging adversely impacts all people, women with germline mutations in BRCA1 or BRCA2 genes are considered specifically high risk for BC, having an average cumulative risk by age 70y of 65% in BRCA1-mutation carriers and up to 45% in BRCA2-mutation carriers [16], compared with a lifetime risk of 13% in average risk women. Here, BRCA2 is linked to breast cancer.