This study demonstrated that antidiabetic effect of APLE in experimental diabetes mellitus in rats is mediated through multiple mechanisms including inverse modulation of insulin and GLP-1 with glucagon, inhibition of α-amylase and α-glucosidase enzymatic activity, free radical scavenging, antioxidant, and recovery of necro-apoptosized pancreatic β-cells. This evidence concerns the gene INS and diabetes mellitus.