In addition to lowering blood sugar, SGLT2 inhibitors can also inhibit the expression of SGLT2 in the renal proximal tubules to promote sodium diuresis and glucose permeable diuresis [6, 7], increase urate excretion to reduce uric acid [8], lower blood pressure [9] by excreting sodium and reducing weight and uric acid, and improve the prognosis of heart failure [10]. This evidence concerns the gene SLC5A2 and heart failure.