There were differences between the amount of IgM in CHF rats (n = 10) and graft-treated CHF rats (n = 8) at baseline (0.33 ± 0.01 versus 0.29 ± 0.01 mg/mL, p = 0.0073) and between CHF rats (n = 5) and graft-treated rats (n = 8) at 21 days post-graft therapy (0.34 ± 0.01 versus 0.55 ± 0.08 mg/mL, p = 0.0462). Here, CD40LG is linked to congestive heart failure.