In contrast, G-MDSC from severe COVID-19 patients had increased expression of genes associated with granulocyte functions/degranulation and chronic inflammation including Arg1, MMP8, MMP9, S100A8 and A9, MPO, IL18RA, elastase, PRTN3 (azurophilic granule protein 7) (Figure 4K). This evidence concerns the gene IGKV1D-22 and COVID-19.