SHMT2 and acute myeloid leukemia: In the context of acute myeloid leukemia (AML), we previously demonstrated that MYC binds at promoter sites of one-carbon folate pathway enzymes, such as serine hydroxymethyltransferase 2 (SHMT2), NAD-dependent mitochondrial methylenetetrahydrofolate dehydrogenase/cyclohydrolase (MTHFD2) and methylenetetrahydrofolate dehydrogenase 1 like (MTHFD1L) [13].