Type I IFN production in tumors promoted by the activation of the cGAS-STING pathway22 in response to specific agonists20,21,65 and even fractionated radiotherapy24,25,66 has been shown to enhance the response not only in the local tumor but also recruiting lymphocytes and promoting the systemic response in the abscopal tumor. The gene discussed is STING1; the disease is neoplasm.