ISG20L2 and breast cancer: Compared to normal mammary epithelial cell (MCF10A), the RCPs of each hub gene in both breast cancer cell lines (MCF7 and MDA-MB-231) showed a significant increase (p < 0.05), but the RCPs of ISG20L2 were reduced and the LSM4 were similar as observed in SKBR3 cell (Fig. 8e–i).