To explore the diagnostic performance of each hub gene in breast cancer, we first performed ROC analysis to assess the diagnostic performances of the four hub genes for detecting breast cancer using TCGA_BRCA dataset, and their AUC values (CENPL AUC: 0.934, LSM4 AUC: 0.948, MRPL3 AUC: 0.891, ISG20L2 AUC: 0.918) were showed in Fig. 5a. The gene discussed is ISG20L2; the disease is breast cancer.