In this study, our data not only showed the expression level of CENPL, ISG20L2, LSM4 and MRPL3 were strongly associated with age, lymph node metastasis and higher SBR grade, but also significantly upregulated in triple negative breast cancer patients compared to non-triple negative breast cancer. Here, ISG20L2 is linked to metastatic malignant neoplasm in the lymph nodes.