IGFBP3 and psychiatric disorder: To determine whether the plasma concentrations of BDNF, NT-3, IGF-1, IGF-2 and IGFBP-3 in alcohol-abstinent AUD patients were influenced by the presence of psychiatric comorbidities, we used Student’s t test to examine the differences between patients with and without mood and anxiety disorders, as these were the most common psychiatric disorders among the study population (see Table 2).