To determine whether the plasma concentrations of BDNF, NT-3, IGF-1, IGF-2 and IGFBP-3 in alcohol-abstinent AUD patients were influenced by the presence of psychiatric comorbidities, we used Student’s t test to examine the differences between patients with and without mood and anxiety disorders, as these were the most common psychiatric disorders among the study population (see Table 2). This evidence concerns the gene IGF1 and psychiatric disorder.